Antigenic variance.

نویسنده

L Kingsford

چکیده

Antigenic variance may be defined as phenotypic expressions that are due to slight differences in gene sequences coding for viral proteins with antigenic reactivity (CALISHER 1988). Evidence for antigenic variance due to mutations and reassortment in the Bunyaviridae family is great and has been obtained by several different approaches. The main intent of this review, however, is not to discuss all the work that has led to the current proposed classification or to review all the papers describing antigenic variance of viruses in the family but to show how the use of monoclonal antibodies, oligonucleotide mapping, sequencing, etc., has led to a better·understanding of the relationships of the viruses within the various genera. It is also hoped that one will acquire a better understanding of the need to examine and compare these viruses at all levels from gene coding strategies and replication through structure and function of

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